ABSTRACT
Objective :To explore predictive value of thyrotropic—stimulating hormone (TSH) and total bilirubin (TBIL) for prognosis in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).Methods :Accord—ing to serum TBIL and TSH levels ,a total of 156 CHD patients undergoing PCI in our hospital from Feb 2015 to Apr 2017 were divided into high TSH group (n＝72) ,low TSH group (n＝84) and high TBIL group (n＝94) ,low TBIL group (n＝62).Clinical indexes ,coronary disease feature and PCI condition were compared between different TSH and TBIL level groups.The survival condition in followed up within one year were compared between different TBIL and TSH level group . Results :Compared with low TSH group ,there were significant rise in percentages of hypertension and smokers ,Hb and SUA levels ,LVEDd and LVEF ,and significant reductions in levels of FBG and hsCRP in high TSH group ,P＝0.001 all. Compared with low TBIL group ,there were significant reductions in percentages of hyperlipidemia and DM ,Hb level , LVEDd and LVEF ,and significant rise in hsCRP level in high TBIL group , P＜0.01 all.Compared with low TSH group , there were significant rise in number of implanted stents and stent length in high TSH group , P＜0.01 both ;compared with low TBIL group ,there were significant reductions in percentage of opening lesion ,number of implanted stents and stent length in high TBIL group , P＜0.05 or ＜0.01. Incidence rates of MACE in high TSH group and low TBIL group were significantly higher than those of low TSH group and high TBIL group respectively (19.44% vs.4.76%,25.81% vs. 4.26%) , P＜0.01 both .Kaplan—Meier survival analysis indicated that no—MACE survival rate of high TSH group was sig—nificantly lower than that of low TSH group (83.33% vs.95.24%, P＝0.029) ,and that of low TBIL group was signifi—cantly lower than that of high TBIL group (74.19% vs.95.74%, P＝0.001).Conclusion :Serum levels of TSH and TBIL before PCI are related to prognosis in CHD patients undergoing PCI .Those with high TSH and low TBIL levels before PCI possess poorer prognosis .
ABSTRACT
OBJECTIVE:To explore the effectiveness and safety of pranoprofen combined with sodium hyaluronate in the treat-ment of moderate and severe dry eyes. METHODS:180 patients with moderate and severe dry eyes were divided into observation group and control group by random number table method,with 90 cases in each group. Control group was given Sodium hyaluro-nate eye drops,one drop each time,tid,and received physical therapy as cleaning eyelid,hot compress and glandulae tarsales mas-sage. Observation group was additionally given Pranoprofen eye drops,one drop each time,tid. A treatment course lasted for 2 weeks. The monocular corneal fluorescence staining score,break-up time of tear film(BUT),dry eye symptom scores,ShirmerⅠtest (SIT) before and after treatment,clinical efficacy and ADR were compared between 2 groups. RESULTS:2,4 weeks after treatment,monocular corneal fluorescence staining scores and dry eye symptom scores of 2 groups were significantly lower than be-fore treatment;BUT and SIT were significantly longer than before;those indexes after 4 weeks of treatment were significantly bet-ter than after 2 weeks of treatment;those indexes of observation group after 2,4 weeks of treatment were significantly better than those of control group at the same time,with statistical significance (P0.05). CONCLUSIONS:For moderate and severe dry eyes,prano-profen combined with sodium hyaluronate can effectively control ocular inflammation and improve tear film stability. It shows defi-nite therapeutic efficacy and good safety.